6-Chloro-2,3-diaminotoluene hydrochloride
[CAS 1087743-89-2]

Identification

• Classification: Chemical reagent >> Organic reagent >> Amine salt (ammonium salt)
• Name: 6-Chloro-2,3-diaminotoluene hydrochloride
• Synonyms: 4-chloro-3-methylbenzene-1,2-diamine hydrochloride
• Molecular Formula: C₇H₁₀Cl₂N₂
• Molecular Weight: 193.07
• CAS Registry Number: 1087743-89-2
• EC Number: 814-904-5
• SMILES: CC1=C(C=CC(=C1N)N)Cl.Cl

Safety Data

• Hazard Symbols: GHS02 DangerGHS02
• Risk Statements: H228-H252
• Safety Statements: P210-P235-P240-P241-P280-P370+P378-P407-P410-P413-P420

Hazard Classification

Hazard	Class	Category Code	Hazard Statement
Flammable solids	Flam. Sol.	2	H228
Self-heating substances or mixtures	Self-heat.	2	H252

chemBlink Chemical Story

Two neighboring amino groups make an aromatic ring a potential starting point for building another ring. In 4-chloro-3-methylbenzene-1,2-diamine hydrochloride, CAS 1087743-89-2, those groups sit next to one another, while chlorine and methyl substituents mark two other positions. The supplied alternative name, 6-chloro-2,3-diaminotoluene hydrochloride, describes the same substitution pattern using toluene as the numbering framework. Following the connectivity is more reliable than comparing the numbers in the two names directly.

The hydrochloride is a defined salt form of the diamine, not a benzene ring carrying two covalent chlorine substituents. One chlorine belongs to the aromatic skeleton and the other is chloride associated with hydrochloric acid. Manufacturer records give the composition C₇H₁₀Cl₂N₂. The two amino groups do not mean that the registered product must be a dihydrochloride; salt stoichiometry has to be read independently from the number of nitrogen atoms.

The adjacent amino groups provide a useful structural connection to benzimidazole chemistry. In the general chemistry of ortho-phenylenediamines, both nitrogens can participate in formation of a fused nitrogen-containing ring with a suitable carbon-containing partner. This explains why substituted aromatic diamines are useful frameworks to consider in heterocycle synthesis. It does not identify a particular approved drug or prove that an arbitrary condensation has been demonstrated with this exact salt.

Chlorine and methyl substitution also make the two sides of the aromatic framework nonequivalent. When interpreting a downstream structure, the original atom positions must be tracked rather than assuming that either amino group gives an identical labeling outcome. The salt form further affects which nitrogen species are available under the reaction conditions. The verified public sources reviewed here establish the exact reagent identity and substitution pattern, but do not support a distinctive discovery history or a specific independently documented end-use for this CAS. Its defensible story is the preparation of a pre-substituted platform for subsequent heterocyclic chemistry.

References:
1. BLD Pharm. 4-Chloro-3-methylbenzene-1,2-diamine hydrochloride; CAS 1087743-89-2. https://www.bldpharm.com/products/1087743-89-2.html
2. Apollo Scientific. 4-Chloro-3-methylbenzene-1,2-diamine hydrochloride; MFCD23135721; CAS 1087743-89-2. https://store.apolloscientific.co.uk/product/4-chloro-3-methylbenzene-12-diamine-hydrochloride